Endocrine Abstracts

Background and aims: The rs5219 variant in the KCNJ11 have been consistently associated with type 2 diabetes (T2D) and therapeutic response to sulfonylureas in type 2 diabetic patients. However, the impact of KCNJ11 genetic polymorphism on the antidiabetic efficacy of vildagliptin has not yet been evaluated. This study was aimed to investigate the association of KCNJ11 rs5219 with vildagliptin glucose lowering ability by monitoring continuous blood glucose profile.<p class...

Objectives: Primary aldosteronism (PA) is considered to be the most common cause of secondary hypertension. Therefore, a relevance of early diagnosis of PA is obvious.Methods: We evaluated 98 patients with hypertension in age 47.8±1.4 years. We measured serum potassium by indirect porentiometry, serum aldosterone and plasma rennin activity (PRA) by RIA, serum corticosterone (B), 18-hydroxycorticosterone (18-OH-B), 11-deoxycorticosterone (DOC), 11-de...

Introduction: Prolonged QTc interval is a known risk factor for developing ventricular tachyarrhythmias. QTc prolongation is often reported in patients with pheochromocytoma, however the literature data on this issue are rather heterogeneous. Here we report the results of QTc measurement in patients with pheochromocytoma and paraganglioma (PPGL) in comparison to hormonally inactive benign adrenal tumors.Methods: The test group included 204 patients with ...